The relationship between IEL and climate change is only bound to increase in the next years. Latin American States have built a sizeable toolbox to fight against Climate Change . Though the toolbox includes orthodox tools like adaptation and mitigation, it also envisages, more innovative measures closely intertwined with trade and investment flows. This paper argues that Latin American States are a fertile ground to innovate in the fight against climate change. Specifically, this paper shows how the new international trade and investment agreements, and domestic legislation adopted in the Latin American region in the last years are reflecting the increasing impact that Climate Change is having in the regulation of trade and investment in the region. The paper also posits that the Latin American approach to the relationship between trade, investment and climate change can serve as a template for the Global South.