Human dignity and autonomy are two concurring grounds brought to bear in moral dilemmas. These often point toward contrary solutions although harmonizing arguments may be provided (such as one recently undertaken by the German Constitutional Court). I gather an argument explaining the role of human dignity as a constraint on claiming exclusivity for naturalist or supernaturalist premises. This secures convergence in our pluralist societies but leaves a number of (publicly) relevant questions open. I discuss this point through the idea of metatheoretical uncertainty and the role of “in dubio pro X” clauses.