Latin America is characterized by diversity and its indigenous peoples are no exception: According to the ECLAC, in 2010 around 45 million persons from 826 different indigenous peoples lived in the region. In order to approach the relationship between the protection of human rights in the region and international economic law (IEL), taking into account the different cosmovisions of development from Latin American indigenous peoples becomes crucial. In order to avoid imposing Western interpretations of those rights to such peoples, it is vital to acknowledge the epistemological differences between the mainstream perspective and theirs. The concept of the Ius Constitutionale Commune en América Latina (ICCAL) is particularly useful for this purpose, since it affirms the interconnection of elements from various legal systems in the region. In this regard, an internal dialogue among these different conceptions within ICCAL, and between ICCAL and IEL is arguably needed.